Assembly of the RAG1/RAG2 Synaptic Complex
نویسندگان
چکیده
منابع مشابه
Assembly of the mariner Mos1 synaptic complex.
The mobility of transposable elements via a cut-and-paste mechanism depends on the elaboration of a nucleoprotein complex known as the synaptic complex. We show here that the Mos1 synaptic complex consists of the two inverted terminal repeats of the element brought together by a transposase tetramer and is designated paired-end complex 2 (PEC2). The assembly of PEC2 requires the formation of a ...
متن کاملPRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly
Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reconstituted single vesicle and bulk fusion assays, combined with live cell imaging of single exocyt...
متن کاملSphingosine Facilitates SNARE Complex Assembly and Activates Synaptic Vesicle Exocytosis
Synaptic vesicles loaded with neurotransmitters fuse with the plasma membrane to release their content into the extracellular space, thereby allowing neuronal communication. The membrane fusion process is mediated by a conserved set of SNARE proteins: vesicular synaptobrevin and plasma membrane syntaxin and SNAP-25. Recent data suggest that the fusion process may be subject to regulation by loc...
متن کاملIdentification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly.
Assembly of the three neuronal membrane proteins synaptobrevin, syntaxin, and SNAP-25 is thought to be one of the key steps in mediating exocytosis of synaptic vesicles. In vivo and in vitro, these proteins form a tight complex. Assembly is associated with a large increase in alpha-helical content, suggesting that major structural and conformational changes are associated with the assembly reac...
متن کاملassembly of biosolar cells by using n719-bacteriorhodopsin complex
today, using new and renewable energy sources to replace fossil fuels is greatly expanded. the solar cells are devices that convert solar energy to electrical energy. solar cells based on organic materials, especially proteins, are one of these solar cells. for example, bacteriorhodopsin (br) which is one of the membrane proteins in halobacterium salinarum could be used in solar cells and parti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2002
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.22.1.69-77.2002